CAS No. 790186-68-4
Batch:
Purity:99.99
Chemical Structure
Check the
GW284543 (UNC10225170)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 6,7-dimethoxy-N-(3-phenoxyphenyl)quinolin-4-amine | |
|---|---|---|
| CAS Number | 790186-68-4 | |
| Molecular Formula |
C23H20N2O3 |
|
| Molecular Weight (MW) | 372.42 | |
| SMILES | COC1=CC2=C(C=C1OC)C(=CC=N2)NC3=CC(=CC=C3)OC4=CC=CC=C4 | |
| InChIKey | LEEMRFWMAIVHQY-UHFFFAOYSA-N |
Biological Activity
GW284543 (UNC10225170) is a selective MEK5 inhibitor that suppresses MEK5 catalytic activity in a dose-dependent manner. Targeted inhibition of MEK5 leads to marked reductions in downstream ERK5 phosphorylation (pERK5) and decreases endogenous MYC protein expression. Blockade of the MEK5/ERK5 signaling axis impairs downstream oncogenic transcription, resulting in reduced cancer cell growth and survival phenotypes. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
9 mg/mL
(24.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.