CAS No. 1402821-41-3
Batch:
Purity:99.89
Chemical Structure
Check the
GV-58
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R)-2-[[6-[(5-methylthiophen-2-yl)methylamino]-9-propylpurin-2-yl]amino]butan-1-ol | |
|---|---|---|
| CAS Number | 1402821-41-3 | |
| Molecular Formula |
C18H26N6OS |
|
| Molecular Weight (MW) | 374.50 | |
| SMILES | CCC[N]1C=NC2=C(NCC3=CC=C(C)S3)N=C(NC(CC)CO)N=C12 | |
| InChIKey | DPTXJOUVBMUSGY-CYBMUJFWSA-N |
GV-58 is a selective agonist of N-type and P/Q-type voltage-gated Ca2+ channels. Compared to roscovitine, GV-58 exhibits a 3- to 4-fold more potent Ca2+ channel agonist effect with reduced cyclin-dependent kinase inhibition. By slowing channel deactivation, GV-58 increases presynaptic Ca2+ influx during activity, promoting synaptic vesicle fusion and neurotransmitter release at neuromuscular junctions to strengthen synaptic transmission. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 75 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.