CAS No. 6197-39-3
Batch:
Purity:99.94
Chemical Structure
Check the
Guvacoline hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 6197-39-3 | |
|---|---|---|
| Molecular Formula |
C7H11NO2.ClH |
|
| Molecular Weight (MW) | 177.63 | |
| SMILES | Cl.COC(=O)C1=CCCNC1 |
Guvacoline hydrochloride is a pyridine alkaloid that acts as an agonist at muscarinic acetylcholine receptors (mAChR) without significantly activating nicotinic acetylcholine receptors. In tissue preparations, it functions as a full agonist at both atrial and ileal muscarinic receptors. Activation of these muscarinic receptor pathways mediates downstream cholinergic signaling involved in gastrointestinal motility and cardiac tissue regulation. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
36 mg/mL
(202.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 36 mg/mL |
| Ethanol | 36 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Guvacoline hydrochloride Solubility in DMSO
- Guvacoline hydrochloride Stock Solution
- Guvacoline hydrochloride Storage
- Guvacoline hydrochloride Stability
- Guvacoline hydrochloride Molecular Weight
- Guvacoline hydrochloride SMILES
- Guvacoline hydrochloride Chemical Structure (2D and 3D)
- Guvacoline hydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.