CAS No. 6027-91-4
Batch:
Purity:99.73
Chemical Structure
Check the
Guvacine hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 6027-91-4 | |
|---|---|---|
| Molecular Formula |
C6H10ClNO2 |
|
| Molecular Weight (MW) | 163.6 | |
| SMILES | Cl.OC(=O)C1=CCCNC1 |
Biological Activity
Guvacine hydrochloride is an Areca catechu alkaloid and GABA transporter inhibitor displaying modest selectivity across GABA transporter subtypes, inhibiting human GAT-1, rat GAT-1, rat GAT-2 (IC, human GAT-3, rat GAT-3, and human BGT-3. By blocking GABA reuptake into neurons and glia, it enhances synaptic GABA signaling and modulates inhibitory neurotransmission in the central nervous system. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 33 mg/mL |
| DMSO |
16 mg/mL
(97.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.