CAS No. 95975-55-6

Batch: Purity:99.91
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Guggulsterone E&Z Chemical Structure
Chemical Structure
Check the Guggulsterone E&Z product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
CAS Number 95975-55-6
Molecular Formula

C21H28O2
Molecular Weight (MW) 312.45
SMILES CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
InChIKey WDXRGPWQVHZTQJ-OSJVMJFVSA-N

Ordering Information

Biological Activity

Guggulsterone E&Z is a plant-derived bioactive steroid that acts as an antagonist ligand for the farnesoid X receptor (FXR). By inhibiting FXR activation, it downregulates the expression of bile acid transport genes and modulates lipid metabolism pathways. This receptor antagonism enhances bile acid excretion and lowers serum cholesterol levels, contributing to its hypolipidemic activity in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 21 mg/mL (67.21 mM) ; Warmed with 60°C water bath ; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.