CAS No. 118-00-3

Batch: Purity:99.83
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Guanosine Chemical Structure
Chemical Structure
Check the Guanosine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
CAS Number 118-00-3
Molecular Formula

C10H13N5O5
Molecular Weight (MW) 283.24
SMILES C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(NC2=O)N
InChIKey NYHBQMYGNKIUIF-UUOKFMHZSA-N

Biological Activity

Guanosine is an endogenous purine nucleoside involved in purine metabolic pathways and extracellular purinergic signaling. It acts as a bioactive neuromodulator that influences intracellular signaling cascades, including the MAPK and PI3K/AKT pathways. Downstream, guanosine exerts neuroprotective, trophic, and anti-inflammatory effects, promoting neuronal survival, stimulating neurite outgrowth, and protecting neural tissue against oxidative damage and excitotoxicity. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 56 mg/mL (197.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Rathbone MP, et al. Prog Neurobiol. 1999;59(6):663-90.

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Note: Technical data last updated: Sep 1, 2026.