CAS No. 645-43-2
Batch:
Purity:99.91
Chemical Structure
Check the
Guanethidine Monosulfate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[2-(azocan-1-yl)ethyl]guanidine;sulfuric acid | |
|---|---|---|
| CAS Number | 645-43-2 | |
| Molecular Formula |
C10H22N4.H2SO4 |
|
| Molecular Weight (MW) | 296.39 | |
| SMILES | C1CCCN(CCC1)CCN=C(N)N.OS(=O)(=O)O | |
| InChIKey | YUFWAVFNITUSHI-UHFFFAOYSA-N |
Guanethidine monosulfate is an antihypertensive agent that acts as a selective adrenergic neuron blocking agent. It enters presynaptic sympathetic nerve terminals via the norepinephrine transporter, where it inhibits the storage and subsequent release of norepinephrine from post-ganglionic adrenergic nerves. This depletion and blockade disrupt sympathetic signaling, leading to decreased peripheral vascular resistance and reduced smooth muscle tone. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 59 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Guanethidine Monosulfate Solubility in DMSO
- Guanethidine Monosulfate Stock Solution
- Guanethidine Monosulfate Storage
- Guanethidine Monosulfate Stability
- Guanethidine Monosulfate Molecular Weight
- Guanethidine Monosulfate SMILES
- Guanethidine Monosulfate Chemical Structure (2D and 3D)
- Guanethidine Monosulfate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.