GsMTx4

Synonyms:

GsMTx4 (Grammostola spatulata mechanotoxin 4, M-theraphotoxin-Gr1a, M-TRTX-Gr1a) is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs).

GsMTx4 Chemical Structure

GsMTx4 Chemical Structure

CAS: 1209500-46-8

Selleck's GsMTx4 has been cited by 4 publications

Purity & Quality Control

Batch: Purity: 99.82%
99.82

GsMTx4 Related Products

Choose Selective Mechanosensitive Channel Inhibitors

Biological Activity

Description GsMTx4 (Grammostola spatulata mechanotoxin 4, M-theraphotoxin-Gr1a, M-TRTX-Gr1a) is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs).
Targets
MSCs [1]
In vitro
In vitro

Pretreatment of GsMTx4 and BAPTA-AM suppress the Yoda1-induced accumulation of HIF-1alpha, NFATC1, and NFATC3 proteins and also suppress Yoda1-induced VEGF-A expression at the mRNA and protein levels.[2]

Cell Research Cell lines BMDMs, RAW264.7 cells
Concentrations 5, 10 µM
Incubation Time 30 min
Method

To study the effect of mechanical stretching, BMDMs or RAW264.7 cells were treated with Yoda1, with or without pretreatment with inhibitors for 30 min. The inhibitors included cyclosporin A, FK506, echinomycin, GsMTx4, BAPTA-AM and RN-1734. In some experiments, BMDMs were treated with GSK1016790A.

(Data sourced from selleck products)

Chemical Information & Solubility

Molecular Weight 4095.86 Formula

C185H273N49O45S6

CAS No. 1209500-46-8 SDF --
Density 95.0~105.0%
Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

Water : 100 mg/mL


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In vivo
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