CAS No. 2451862-42-1
Batch:
Purity:99.84
Chemical Structure
Check the
GSK778 (iBET-BD1)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[2-(methoxymethyl)-1-[(1R)-1-phenylethyl]-8-[[(3S)-pyrrolidin-3-yl]methoxy]imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole | |
|---|---|---|
| CAS Number | 2451862-42-1 | |
| Molecular Formula |
C30H33N5O3 |
|
| Molecular Weight (MW) | 511.61 | |
| InChIKey | ZORLJXWXFABTPZ-CTNGQTDRSA-N |
GSK778 (iBET-BD1) is a selective BD1 bromodomain inhibitor of BET proteins, targeting BRD2 BD1 (IC50 75 nM), BRD3 BD1 (IC50 41 nM), BRD4 BD1 (IC50 41 nM), and BRDT BD1 (IC50 143 nM). By selectively binding to the first bromodomain, GSK778 displaces BET proteins from chromatin, suppressing transcription of oncogenes such as MYC and downregulating pro-inflammatory gene expression pathways, leading to potent antiproliferative and antitumor phenotypes. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(195.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.