CAS No. 1910124-24-1
Batch:
Purity:99.44
Chemical Structure
Check the
GSK6853
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[1,3-dimethyl-6-[(2R)-2-methylpiperazin-1-yl]-2-oxobenzimidazol-5-yl]-2-methoxybenzamide | |
|---|---|---|
| CAS Number | 1910124-24-1 | |
| Molecular Formula |
C22H27N5O3 |
|
| Molecular Weight (MW) | 409.48 | |
| SMILES | CC1CNCCN1C2=CC3=C(C=C2NC(=O)C4=CC=CC=C4OC)N(C(=O)N3C)C | |
| InChIKey | FQWDVNSBYDXPIO-CQSZACIVSA-N |
GSK6853 is a selective benzimidazolone BRPF1 inhibitor with a pin TR-FRET binding assays, displaying over 1600-fold selectivity for BRPF1 over other bromodomains. As a key subunit of MOZ/MORF histone acetyltransferase complexes, BRPF1 inhibition by GSK6853 displaces BRPF1 from chromatin, leading to down-regulation of chromatin-dependent gene expression and suppression of cell proliferation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
81 mg/mL
(197.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 81 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.