CAS No. 1616391-87-7
Batch:
Purity:99.00
Chemical Structure
Check the
GSK591
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamide | |
|---|---|---|
| CAS Number | 1616391-87-7 | |
| Molecular Formula |
C22H28N4O2 |
|
| Molecular Weight (MW) | 380.48 | |
| SMILES | C1CC(C1)NC2=NC=CC(=C2)C(=O)NCC(CN3CCC4=CC=CC=C4C3)O | |
| InChIKey | TWKYXZSXXXKKJU-FQEVSTJZSA-N |
GSK591 is a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). By inhibiting PRMT5 catalytic function, the compound blocks symmetric dimethylation of arginine residues on key histone and non-histone protein targets. This mechanism disrupts pre-mRNA splicing and downstream gene expression pathways, leading to cell cycle arrest and impaired proliferation in PRMT5-dependent tumor models. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 76 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.