CAS No. 2226735-55-1
Batch:
Purity:99.86
Chemical Structure
Check the
GSK'547
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-[4-[(3S)-3-(3,5-difluorophenyl)-3,4-dihydropyrazole-2-carbonyl]piperidin-1-yl]pyrimidine-4-carbonitrile | |
|---|---|---|
| CAS Number | 2226735-55-1 | |
| Molecular Formula |
C20H18F2N6O |
|
| Molecular Weight (MW) | 396.39 | |
| SMILES | C1CN(CCC1C(=O)N2C(CC=N2)C3=CC(=CC(=C3)F)F)C4=NC=NC(=C4)C#N | |
| InChIKey | SJVGFKBLUYAEOK-SFHVURJKSA-N |
GSK'547 is a highly selective and potent inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIP1/RIPK1). By blocking RIPK1 kinase activity, it disrupts the formation of necroptotic signaling complexes such as the necrosome, thereby inhibiting TNF-α-induced necroptosis and programmed inflammatory cell death pathways. This targeted inhibition effectively dampens downstream pro-inflammatory cytokine production and suppresses systemic inflammation in preclinical models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
29 mg/mL
(73.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.