CAS No. 1652591-81-5
Batch:
Purity:99.98
Chemical Structure
Check the
GSK484 Hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(3S,4R)-3-amino-4-hydroxypiperidin-1-yl]-[2-[1-(cyclopropylmethyl)indol-2-yl]-7-methoxy-1-methylbenzimidazol-5-yl]methanone;hydrochloride | |
|---|---|---|
| CAS Number | 1652591-81-5 | |
| Molecular Formula |
C27H32ClN5O3 |
|
| Molecular Weight (MW) | 510.03 | |
| SMILES | CN1C2=C(C=C(C=C2OC)C(=O)N3CCC(C(C3)N)O)N=C1C4=CC5=CC=CC=C5N4CC6CC6.Cl | |
| InChIKey | MULKOGJHUZTANI-ADMBKAPUSA-N |
GSK484 Hydrochloride is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor with an IC50 ofin the absence of calcium. By inhibiting PAD4 catalytic activity, GSK484 blocks protein arginine citrullination, particularly targeting histone H3. This inhibition suppresses neutrophil extracellular trap formation and reduces inflammatory phenotypes in cellular models. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(196.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | 8 mg/mL |
| DMSO |
100 mg/mL
(196.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Gsk484 Hydrochloride Mechanism of Action: PAD4 Inhibition in Neutrophil Research
- Gsk484 Hydrochloride Working Concentration | Cell Culture | Treatment
- GSK484 Hydrochloride Solubility in DMSO
- GSK484 Hydrochloride Storage
- GSK484 Hydrochloride Stability
- Gsk484 Hydrochloride Combination Database
- GSK484 Hydrochloride Molecular Weight
- GSK484 Hydrochloride SMILES
- GSK484 Hydrochloride Chemical Structure (2D and 3D)
- Gsk484 Hydrochloride Sigma (SML1658)? Try a better option.
- Gsk484 Hydrochloride MedChemExpress (HY-100514)? Try a better option.
- Gsk484 Hydrochloride Cayman (17488)? Try a better option.
- Gsk484 Hydrochloride Abcam (ab223598)? Try a better option.
- GSK484 Hydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.