CAS No. 1622849-58-4
Batch:
Purity:99.3
Chemical Structure
Check the
GSK481
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide | |
|---|---|---|
| CAS Number | 1622849-58-4 | |
| Molecular Formula |
C21H19N3O4 |
|
| Molecular Weight (MW) | 377.39 | |
| SMILES | CN1C2=CC=CC=C2OCC(C1=O)NC(=O)C3=NOC(=C3)CC4=CC=CC=C4 | |
| InChIKey | KNOUWGGQMADIBV-KRWDZBQOSA-N |
GSK481 is a small-molecule inhibitor targeting receptor-interacting protein kinase 1 (RIP1/RIPK1). By selectively suppressing the kinase activity of RIP1, GSK481 disrupts the assembly and activation of downstream necroptotic signaling complexes. This inhibition effectively hinders necrotic cell death and blocks the release of pro-inflammatory cellular mediators, thereby modulating inflammatory cellular processes mediated by the RIP1 pathway. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(198.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.