CAS No. 1628332-52-4
Batch:
Purity:99.87
Chemical Structure
Check the
GSK467
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(1-benzylpyrazol-4-yl)oxy-3H-pyrido[3,4-d]pyrimidin-4-one | |
|---|---|---|
| CAS Number | 1628332-52-4 | |
| Molecular Formula |
C17H13N5O2 |
|
| Molecular Weight (MW) | 319.32 | |
| SMILES | C1=CC=C(C=C1)CN2C=C(C=N2)OC3=NC4=C(C=CN=C4)C(=O)N3 | |
| InChIKey | ZTYRLXUTLYBVHH-UHFFFAOYSA-N |
GSK467 is a cell-penetrant and selective inhibitor of histone lysine demethylase 5B (KDM5B, also known as JARID1B or PLU1), displaying marked selectivity over KDM4C, KDM6, and other Jumonji domain-containing family members. Target inhibition elevates intracellular levels of histone H3 lysine 4 trimethylation (H3K4me3), disrupting chromatin-mediated transcriptional repression and suppressing downstream cellular proliferation in drug-tolerant cancer models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(25.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | ˂1 mg/mL |
| Ethanol | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.