CAS No. 1010411-21-8

Batch: Purity:98.59
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GSK369796 Dihydrochloride Chemical Structure
Chemical Structure
Check the GSK369796 Dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(tert-butylamino)methyl]-5-[(7-chloroquinolin-4-yl)amino]phenol;dihydrochloride
CAS Number 1010411-21-8
Molecular Formula

C20H24Cl3N3O
Molecular Weight (MW) 428.78
SMILES CC(C)(C)NCC1=C(C=C(C=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O.Cl.Cl
InChIKey UDVALKJFXQVZSI-UHFFFAOYSA-N

Ordering Information

Biological Activity

GSK369796 Dihydrochloride is an orally active 4-aminoquinoline antimalarial agent and an inhibitor of hERG potassium ion channel repolarization with an IC50 of. By disrupting heme detoxification pathways inside the parasite, the compound exhibits potent antiparasitic activity against chloroquine-sensitive and resistant Plasmodium falciparum strains, leading to effective parasite clearance and suppressed infection burden. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 86 mg/mL (200.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 40 mg/mL
Ethanol 10 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.