CAS No. 2170137-61-6

Batch: Purity:99.99
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GSK3685032 Chemical Structure
Chemical Structure
Check the GSK3685032 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethyl-2-pyridinyl]sulfanyl]-2-phenylacetamide
CAS Number 2170137-61-6
Molecular Formula

C22H24N6OS
Molecular Weight (MW) 420.53
InChIKey KNKHRZYILDZLRE-UHFFFAOYSA-N

Ordering Information

Biological Activity

GSK36832 is a non-time-dependent, highly selective enzymatic inhibitor of DNA methyltransferase 1 (DNMT1, IC= displaying over-fold selectivity relative to DNMT3A/3L and DNMT3B/3L. By reversibly inhibiting DNMT1, GSK3685032 promotes robust DNA hypomethylation and reactivates hypermethylated tumor suppressor genes. This epigenetic modulation downstream suppresses cancer cell proliferation and exhibits marked antitumor activity in preclinical models of acute myeloid leukemia. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 1 mg/mL (2.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.