CAS No. 1622848-92-3
| IUPAC Name | 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide | |
|---|---|---|
| CAS Number | 1622848-92-3 | |
| Molecular Formula |
C20H19N5O3 |
|
| Molecular Weight (MW) | 377.40 | |
| SMILES | CN1C2=CC=CC=C2OCC(C1=O)NC(=O)C3=NNC(=N3)CC4=CC=CC=C4 | |
| InChIKey | LYPAFUINURXJSG-AWEZNQCLSA-N |
GSK2982772 is a potent, ATP-competitive receptor-interacting protein-1 (RIPK1) kinase inhibitor with an IC50 of 16 nM. It demonstrates high kinase selectivity and effectively blocks TNF-induced cellular responses and inflammatory signaling pathways. By inhibiting RIPK1 activation, GSK2982772 suppresses necroptotic cell death and reduces the production of pro-inflammatory cytokines, highlighting its role as a key modulator of systemic inflammatory responses. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(198.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 30 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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