CAS No. 1474110-21-8
Batch:
Purity:99.72
Chemical Structure
Check the
GSK2981278
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1474110-21-8 | |
|---|---|---|
| Molecular Formula |
C25H35NO5S |
|
| Molecular Weight (MW) | 461.61 | |
| SMILES | CCC1=CC=C(C=C1)N(CC(C)C)S(=O)(=O)C2=CC(=C(C=C2)OCC3CCOCC3)CO |
GSK2981278 is a potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (RORγ). By suppressing RORγ transcriptional activity, GSK2981278 inhibits the Th17 cell-mediated signaling pathway. Consequently, it decreases the expression and secretion of pro-inflammatory cytokines, including IL-17A, IL-17F, and IL-22, thereby suppressing inflammatory responses in human peripheral blood mononuclear cells and skin explants. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(199.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 92 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.