CAS No. 850664-21-0
Batch:
Purity:99.64
Chemical Structure
Check the
GSK269962A
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-6-yl]oxyphenyl]-4-(2-morpholin-4-ylethoxy)benzamide | |
|---|---|---|
| CAS Number | 850664-21-0 | |
| Molecular Formula |
C29H30N8O5 |
|
| Molecular Weight (MW) | 570.60 | |
| InChIKey | YOVNFNXUCOWYSG-UHFFFAOYSA-N |
GSK269962A is a potent and selective inhibitor of Rho-associated protein kinase (ROCK), targeting ROCK1 (IC50 = 1.6 nM) and ROCK2 (IC50 = 4 nM). Inhibition of the ROCK signaling pathway reduces smooth muscle contraction and suppresses downstream phosphorylation of myosin light chain. Consequently, GSK269962A exhibits significant vasodilatory and anti-inflammatory activities, demonstrating functional efficacy in modulating vascular tone and smooth muscle relaxation. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(175.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(175.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.