CAS No. 1372540-25-4
| IUPAC Name | 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-morpholin-4-ylbenzimidazole-4-carboxylic acid | |
|---|---|---|
| CAS Number | 1372540-25-4 | |
| Molecular Formula |
C22H22F3N3O3 |
|
| Molecular Weight (MW) | 433.42 | |
| SMILES | CC1=C(C=CC=C1C(F)(F)F)CN2C(=NC3=C(C=C(C=C32)N4CCOCC4)C(=O)O)C | |
| InChIKey | XTKLTGBKIDQGQL-UHFFFAOYSA-N |
GSK2636771 is a potent, orally bioavailable, and selective inhibitor of phosphoinositide 3-kinase beta (PI3Kβ). By targeted inhibition of the PI3Kβ subunit, GSK2636771 disrupts downstream AKT/mTOR signal transduction, resulting in the suppression of cell growth, survival, and proliferation while driving apoptosis in PTEN-deficient tumor models. Loss of the PTEN tumor suppressor creates a selective dependency on PI3Kβ signaling, rendering these cancer cells hyper-sensitive to GSK2636771 inhibition. [1][2]
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Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(198.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
| DMSO |
28 mg/mL
(64.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
54 mg/mL
(124.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
87 mg/mL
(200.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 19 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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