CAS No. 801312-28-7
Batch:
Purity:99.31
Chemical Structure
Check the
GSK256066
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 6-[3-(dimethylcarbamoyl)phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide | |
|---|---|---|
| CAS Number | 801312-28-7 | |
| Molecular Formula |
C27H26N4O5S |
|
| Molecular Weight (MW) | 518.58 | |
| SMILES | CC1=CC(=CC2=C(C(=CN=C12)C(=O)N)NC3=CC(=CC=C3)OC)S(=O)(=O)C4=CC=CC(=C4)C(=O)N(C)C | |
| InChIKey | JFHROPTYMMSOLG-UHFFFAOYSA-N |
Biological Activity
GSK256066 is a selective phosphodiesterase 4 (PDE4) inhibitor that targets PDE4B with an IC50 of 3.2 pM. By elevating intracellular cAMP levels, GSK256066 suppresses pro-inflammatory mediator release, including lipopolysaccharide-induced tumor necrosis factor production in human monocytes and whole blood. Consequently, it demonstrates potent anti-inflammatory activity and reduces pulmonary eosinophilia and neutrophilia in preclinical respiratory disease models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 4-Methylpyridine | 11 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.