CAS No. 1227911-45-6

Batch: Purity:99.96
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GSK2334470 Chemical Structure
Chemical Structure
Check the GSK2334470 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide
CAS Number 1227911-45-6
Molecular Formula

C25H34N8O
Molecular Weight (MW) 462.59
SMILES CC1CCC(CN1C2=NC(=NC(=C2)C3=CC4=C(C=C3)C(=NN4)N)NC)C(=O)NC5CCCCC5
InChIKey QLPHOXTXAKOFMU-WBVHZDCISA-N

Ordering Information

Biological Activity

GSK2334470 is a potent and selective 3-phosphoinositide-dependent protein kinase 1 (PDK1) inhibitor with an IC50 of ~10 nM in cell-free assays. By inhibiting PDK1, it blocks the activation loop phosphorylation of downstream AGC kinase family members, such as SGK, Akt, and S6K1. This suppression disrupts PI3K/PDK1 pathway signaling and impairs downstream cellular function. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 93 mg/mL (201.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 93 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.