CAS No. 1549811-53-1
Batch:
Purity:97.06
Chemical Structure
Check the
GSK199
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(3R)-3-aminopiperidin-1-yl]-[2-(1-ethylpyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methylbenzimidazol-5-yl]methanone;hydrochloride | |
|---|---|---|
| CAS Number | 1549811-53-1 | |
| Molecular Formula |
C24H28N6O2.ClH |
|
| Molecular Weight (MW) | 468.98 | |
| InChIKey | KRGMIOKDGHBYQE-UNTBIKODSA-N |
GSK199 is a reversible and selective inhibitor of peptidyl arginine deiminase 4 (PAD4) with an IC50 ofin the absence of calcium. By inhibiting PAD4, GSK199 blocks histone citrullination and prevents neutrophil extracellular trap (NET) formation. These targeted effects impair inflammatory responses and autoimmune signaling, making GSK199 a valuable chemical probe for studying autoimmune, cardiovascular, and oncological diseases. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(200.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 94 mg/mL |
| Ethanol | 31 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.