CAS No. 817194-38-0
Batch:
Purity:99.23
Chemical Structure
Check the
GSK180736A (GSK180736)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide | |
|---|---|---|
| CAS Number | 817194-38-0 | |
| Molecular Formula |
C19H16FN5O2 |
|
| Molecular Weight (MW) | 365.36 | |
| SMILES | CC1=C(C(NC(=O)N1)C2=CC=C(C=C2)F)C(=O)NC3=CC4=C(C=C3)NN=C4 | |
| InChIKey | HEAIGWIZTYAQTC-UHFFFAOYSA-N |
GSK180736A is a selective inhibitor of G protein-coupled receptor kinase 2 (GRK2), originally developed from Rho-associated protein kinase (ROCK) inhibitor scaffolds. It exhibits high selectivity for GRK2 over GRK1 and GRK5 isoforms. By inhibiting GRK2-mediated receptor phosphorylation, GSK180736A attenuates G protein-coupled receptor desensitization, modulating GPCR signaling pathways and downstream cellular phenotypes. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.