CAS No. 1014691-61-2
Batch:
Purity:99.75
Chemical Structure
Check the
GSK0660
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 1014691-61-2 | |
|---|---|---|
| Molecular Formula |
C19H18N2O5S2 |
|
| Molecular Weight (MW) | 418.49 | |
| SMILES | COC1=C(C=CC(=C1)NC2=CC=CC=C2)NS(=O)(=O)C3=C(SC=C3)C(=O)OC |
Biological Activity
GSK0660 is a selective peroxisome proliferator-activated receptor β/δ (PPARβ/δ) antagonist, exhibiting an IC50 ofin binding assays andin functional antagonist assays. It demonstrates high selectivity over PPARα (IC50 > and PPARγ (IC50 >. Inhibition of PPARβ/δ by GSK0660 regulates lipid metabolism and target gene expression involved in downstream cell proliferation and differentiation pathways. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(200.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.