CAS No. 1373423-53-0
Batch:
Purity:96.20
Chemical Structure
Check the
GSK-J4
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | ethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate | |
|---|---|---|
| CAS Number | 1373423-53-0 | |
| Molecular Formula |
C24H27N5O2 |
|
| Molecular Weight (MW) | 417.50 | |
| InChIKey | WBKCKEHGXNWYMO-UHFFFAOYSA-N |
GSK-J4 is a cell-permeable dual inhibitor of the H3K27me3/me2 histone demethylases JMJD3 and UTX. It inhibits lipopolysaccharide-induced TNF-α production with an IC50 of 9 μM. Downstream, inhibition of these demethylases suppresses inflammatory gene transcription and blunts pro-inflammatory macrophage signaling, demonstrating marked therapeutic efficacy in experimental autoimmune encephalomyelitis and autoimmune disease models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(201.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 42 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.