CAS No. 2703752-81-0
Batch:
Purity:98.819
Chemical Structure
Check the
GSK-872 hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine;hydrochloride | |
|---|---|---|
| CAS Number | 2703752-81-0 | |
| Molecular Formula |
C19H17N3O2S2.ClH |
|
| Molecular Weight (MW) | 419.95 | |
| InChIKey | VKCVPZFWFZKUJY-UHFFFAOYSA-N |
GSK-872 hydrochloride is a selective inhibitor targeting receptor-interacting serine/threonine-protein kinase 3 (RIPK3). By binding the RIP3 kinase domain and blocking its catalytic activity, it disrupts the RIPK3-dependent signaling cascade and downstream phosphorylation of mixed lineage kinase domain-like protein (MLKL). This inhibition prevents necroptotic cell death and suppresses associated HMGB1-mediated inflammatory responses in cellular pathways. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(19.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 3 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.