CAS No. 1253186-56-9
Batch:
Purity:99.38
Chemical Structure
Check the
GSK-7975A
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2,6-difluoro-N-[1-[[4-hydroxy-2-(trifluoromethyl)phenyl]methyl]pyrazol-3-yl]benzamide | |
|---|---|---|
| CAS Number | 1253186-56-9 | |
| Molecular Formula |
C18H12F5N3O2 |
|
| Molecular Weight (MW) | 397.3 | |
| InChIKey | CPYTVBALBFSXSH-UHFFFAOYSA-N |
Biological Activity
GSK-7975A is a potent inhibitor of calcium release-activated calcium (CRAC) channels, functioning as a store-operated calcium entry (SOCE) blocker. By blocking ORAI-mediated calcium influx, it suppresses downstream calcium signaling pathways essential for immune cell activation. This compound effectively inhibits the release of mast cell mediators, including histamine and leukotriene C4, as well as pro-inflammatory cytokines such as IL-5, IL-8, IL-13, and TNF-α.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(198.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 79 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.