CAS No. 101574-65-6
Batch:
Purity:99.89
Chemical Structure
Check the
GSK4716
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 101574-65-6 | |
|---|---|---|
| Molecular Formula |
C17H18N2O2 |
|
| Molecular Weight (MW) | 282.34 | |
| SMILES | CC(C)C1=CC=C(C=C1)C=NNC(=O)C2=CC=C(C=C2)O |
GSK4716 is a selective agonist of estrogen-related receptor gamma (ERRγ) and estrogen-related receptor beta (ERRβ). By binding to ERRγ, it promotes the recruitment of transcriptional coactivators such as PGC-1α, thereby stimulating ERRγ-dependent gene transcription. This activation regulates downstream metabolic pathways, including mitochondrial biogenesis, oxidative phosphorylation, and cellular energy homeostasis in various biological contexts. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
56 mg/mL
(198.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 56 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.