CAS No. 2170136-65-7
Batch:
Purity:99.58
Chemical Structure
Check the
GSK-3484862
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2R)-2-[[3,5-dicyano-6-(dimethylamino)-4-ethyl-2-pyridinyl]sulfanyl]-2-phenylacetamide | |
|---|---|---|
| CAS Number | 2170136-65-7 | |
| Molecular Formula |
C19H19N5OS |
|
| Molecular Weight (MW) | 365.45 | |
| InChIKey | KIEQQZZDWUNUQK-MRXNPFEDSA-N |
Biological Activity
GSK-is a non-covalent, selective inhibitor of DNA methyltransferase 1 (DNMT1) with an ICof. Mechanistically, it competes with hemi-methylated DNA at the active site to block DNMT1 activity, inducing proteasomal degradation of the enzyme and driving global DNA hypomethylation. Downstream, this promoter demethylation triggers transcriptional reactivation of silenced genes and inhibits cancer cell viability, demonstrating therapeutic efficacy in acute myeloid leukemia. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
24 mg/mL
(65.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.