CAS No. 2417307-56-1
Batch:
Purity:99.42
Chemical Structure
Check the
GS-1427
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 2417307-56-1 | |
|---|---|---|
| Molecular Formula |
C35H32F4N6O6 |
|
| Molecular Weight (MW) | 708.66 |
Biological Activity
GS-1427 (Emvistegrast) is a small-molecule quinolone derivative that functions as a potent and selective antagonist of α4β7 integrin. By targeting α4β7 integrin, it disrupts the interaction between α4β7 integrin and mucosal vascular addressin cell adhesion molecule-1 (MAdCAM-1). This inhibition impairs the homing of gut-tropic lymphocytes into intestinal mucosal tissues, leading to reduced downstream intestinal inflammation and therapeutic potential in inflammatory bowel disease.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(141.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(141.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.