CAS No. 1093070-16-6
Batch:
Purity:99.86
Chemical Structure
Check the
GRL0617
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide | |
|---|---|---|
| CAS Number | 1093070-16-6 | |
| Molecular Formula |
C20H20N2O |
|
| Molecular Weight (MW) | 304.39 | |
| SMILES | CC1=C(C=C(C=C1)N)C(=O)NCCC2=CC=CC3=CC=CC=C32 | |
| InChIKey | UVERBUNNCOKGNZ-CQSZACIVSA-N |
GRL0617 is a potent, selective, and competitive noncovalent inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) with an IC50 ofand a Ki of. By inhibiting PLpro deubiquitinating and proteolytic activity, GRL0617 disrupts viral polyprotein processing and host immune evasion pathways, effectively blocking SARS-CoV viral replication in Vero E6 cells with an EC50 of 15 μM without causing cytotoxicity. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(213.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.