CAS No. 415903-37-6

Batch: Purity:99.6
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Grapiprant (CJ-023,423) Chemical Structure
Chemical Structure
Check the Grapiprant (CJ-023,423) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[2-[4-(2-ethyl-4,6-dimethylimidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
CAS Number 415903-37-6
Molecular Formula

C26H29N5O3S
Molecular Weight (MW) 491.61
SMILES CCC1=NC2=C(N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C=C(N=C2C)C
InChIKey HZVLFTCYCLXTGV-UHFFFAOYSA-N

Biological Activity

Grapiprant (CJ-023,423) is a selective prostaglandin EP4 receptor antagonist, demonstrating high binding affinity for human EP4 receptor (Ki 13 nM) and rat EP4 receptor (Ki 20 nM). It selectively inhibits PGE2-induced EP4 signaling, blocking intracellular cyclic AMP accumulation without affecting other prostanoid receptor subtypes. By targeting the EP4 pathway, grapiprant effectively mitigates pain, inflammation, and hyperalgesia in animal models of chronic inflammatory conditions. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 98 mg/mL (199.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 24 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Nakao K, et al. J Pharmacol Exp Ther. 2007;322(2):686-94.

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Note: Technical data last updated: Sep 1, 2026.