CAS No. 2091134-68-6
Chemical Structure
Check the
Golidocitinib(AZD4205)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R)-N-[3-[2-[(3-methoxy-1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propanamide | |
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| CAS Number | 2091134-68-6 | |
| Molecular Formula |
C25H31N9O2 |
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| Molecular Weight (MW) | 489.58 | |
| InChIKey | CVCVOSPZEVINRM-MRXNPFEDSA-N |
Golidocitinib (AZD4205) is a highly selective inhibitor of Janus kinase 1 (JAK1) with an IC50 offor JAK1, demonstrating significantly weaker inhibition against JAK2 (IC50 >. By blocking JAK1 kinase activity, golidocitinib suppresses downstream JAK/STAT signaling pathways, inhibiting tumor cell proliferation and exhibiting marked antitumor efficacy in non-small cell lung cancer (NSCLC) xenograft models. [1]
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Note: Technical data last updated: Sep 1, 2026.