CAS No. 2091134-68-6(free base)
Batch:
Purity:99.71
Chemical Structure
Check the
Golidocitinib 1-hydroxy-2-naphthoate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2091134-68-6(free base) | |
|---|---|---|
| Molecular Formula | ||
| Molecular Weight (MW) | 489.57(free base) |
Golidocitinib 1-hydroxy-2-naphthoate is a derivative of Golidocitinib acting as an oral, potent, and selective inhibitor of Janus kinase 1 (JAK1). By targeting JAK1, it suppresses downstream STAT phosphorylation and impairs JAK/STAT signaling pathways, resulting in the inhibition of cellular proliferation and induction of apoptosis in tumor cells, demonstrating enhanced antitumor activity in hematologic malignancies such as peripheral T-cell lymphoma.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.