CAS No. 2041073-22-5
Batch:
Purity:99.02
Chemical Structure
Check the
GNF4877
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3R)-1-[3-[[3-amino-6-(2-fluoro-5-propan-2-yloxyphenyl)pyrazine-2-carbonyl]amino]-4-pyridinyl]piperidine-3-carboxylic acid | |
|---|---|---|
| CAS Number | 2041073-22-5 | |
| Molecular Formula |
C25H27FN6O4 |
|
| Molecular Weight (MW) | 494.52 | |
| InChIKey | UZIATSFXNVOVFE-OAHLLOKOSA-N |
GNF4877 is an aminopyrazine derivative that acts as a potent dual inhibitor of GSK3β and DYRK1A. By suppressing DYRK1A and GSK3β signaling, it blocks the nuclear export of nuclear factor of activated T-cells (NFATc) proteins, leading to sustained NFAT nuclear localization and transcriptional activity. This downstream activation efficiently promotes pancreatic β-cell proliferation, making GNF4877 a valuable small-molecule tool for diabetes drug discovery and research.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(16.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.