CAS No. 839706-07-9

Batch: Purity:99.82
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GNF-7 Chemical Structure
Chemical Structure
Check the GNF-7 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[4-methyl-3-[1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-3-(trifluoromethyl)benzamide
CAS Number 839706-07-9
Molecular Formula

C28H24F3N7O2
Molecular Weight (MW) 547.53
SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)N3CC4=CN=C(N=C4N(C3=O)C)NC5=CN=C(C=C5)C
InChIKey SZNYUUZOQHNEKB-UHFFFAOYSA-N

Ordering Information

Biological Activity

GNF-7 is a potent type-II kinase inhibitor targeting wild-type Bcr-Abl, c-Abl, and mutant Bcr-Abl isoforms including T315I, M351T, E255V, and G250E. By selectively binding the inactive kinase conformation, GNF-7 blocks Bcr-Abl autophosphorylation and downstream oncogenic signaling pathways. This inhibition effectively impairs proliferation and induces apoptotic cell death in Bcr-Abl-dependent leukemic cell models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 20 mg/mL (36.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.