CAS No. 1496581-76-0
Batch:
Purity:99.9
Chemical Structure
Check the
GNE-3511
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]-2-pyridinyl]amino]pyridine-4-carbonitrile | |
|---|---|---|
| CAS Number | 1496581-76-0 | |
| Molecular Formula |
C23H26F2N6O |
|
| Molecular Weight (MW) | 440.49 | |
| SMILES | FC1(F)CCN(C1)C2=CC(=CC(=N2)NC3=NC=CC(=C3)C#N)C4CCN(CC4)C5COC5 | |
| InChIKey | RHFIAUKMKYHHFA-UHFFFAOYSA-N |
Biological Activity
GNE-3511 is a dual leucine zipper kinase (DLK) inhibitor with a Ki of <. By blocking DLK activity within the MAP3K pathway, GNE-3511 suppresses downstream JNK signaling and c-Jun phosphorylation. This inhibition protects primary neurons against axon degeneration in vitro and demonstrates neuroprotective activity in animal models of neurodegenerative disease. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
44 mg/mL
(99.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.