CAS No. 1802977-61-2
Batch:
Purity:97.04
Chemical Structure
Check the
GNE-140 racemate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-(2-chlorophenyl)sulfanyl-6-(4-morpholin-4-ylphenyl)-6-thiophen-3-ylpiperidine-2,4-dione | |
|---|---|---|
| CAS Number | 1802977-61-2 | |
| Molecular Formula |
C25H23ClN2O3S2 |
|
| Molecular Weight (MW) | 499.05 | |
| InChIKey | GLDDJXYFHWRGPI-UHFFFAOYSA-N |
Biological Activity
GNE-140 racemate is a potent and selective inhibitor of lactate dehydrogenase A (LDH-A). Inhibition of LDH-A disrupts glycolytic signaling and decreases lactate production, thereby impairing metabolic flux and energy generation in tumor cells. Consequently, targeting LDH-A suppresses cell proliferation, motility, and invasive capacity, demonstrating its utility for investigating metabolic vulnerabilities in cancer research. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(16.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.