CAS No. 1449-05-4

Batch: Purity:99.46
Check CoA
Glycyrrhetinic acid Chemical Structure
Chemical Structure
Check the Glycyrrhetinic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
CAS Number 1449-05-4
Molecular Formula

C30H46O4
Molecular Weight (MW) 470.68
SMILES CC1(C2CCC3(C(C2(CCC1O)C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C
InChIKey MPDGHEJMBKOTSU-PMTKVOBESA-N

Ordering Information

Biological Activity

Glycyrrhetinic acid is a bioactive pentacyclic triterpenoid aglycone derived from glycyrrhizic acid that acts as an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD). It exhibits potent anti-proliferative and apoptosis-inducing activities across various cancer cell lines. Inhibition of 11β-HSD and modulation of intrinsic mitochondrial apoptotic pathways lead to cell cycle arrest, elevation of reactive oxygen species, and induction of programmed cell death in target cancer cells.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 94 mg/mL (199.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 46 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.