CAS No. 64480-66-6

Batch: Purity:98.71
Glycoursodeoxycholic acid Chemical Structure
Chemical Structure
Check the Glycoursodeoxycholic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 64480-66-6
Molecular Formula

C26H43NO5

Molecular Weight (MW) 449.62
SMILES CC(CCC(=O)NCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

Ordering Information

Biological Activity

Glycoursodeoxycholic acid is an endogenous acyl glycine and secondary bile acid conjugate that acts as a cytoprotective agent. It inhibits apoptosis and endoplasmic reticulum stress by stabilizing mitochondrial membrane potential and suppressing caspase activation. Furthermore, glycoursodeoxycholic acid reduces reactive oxygen species production and protects cells against toxic bile acid-induced cytotoxicity in hepatic and neuronal cell models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 89 mg/mL (197.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.