CAS No. 16564-43-5

Batch: Purity:98.99
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Glycochenodeoxycholic acid sodium salt Chemical Structure
Chemical Structure
Check the Glycochenodeoxycholic acid sodium salt product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 16564-43-5
Molecular Formula

C26H42NNaO5
Molecular Weight (MW) 471.61
SMILES CC(CCC(=O)NCC(=O)[O-])C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C.[Na+]

Biological Activity

Glycochenodeoxycholic acid sodium salt is an endogenous bile acid conjugate and farnesoid X receptor (FXR) agonist. It plays a key role in lipid solubilization and fat absorption within the digestive system. Beyond its physiological detergent properties, elevated cellular concentrations modulate bile acid homeostasis and induce hepatocyte apoptosis via mitochondrial dysfunction and caspase cascade activation. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 94 mg/mL (199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Parks DJ, et al. Science. 1999;284(5418):1365-8.

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Note: Technical data last updated: Sep 1, 2026.