CAS No. 311795-38-7
Batch:
Purity:99.74
Chemical Structure
Check the
Glutaminase C-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[3-bromo-4-(dimethylamino)phenyl]-2,2-dimethyl-1,3,5,6-tetrahydrobenzo[a]phenanthridin-4-one | |
|---|---|---|
| CAS Number | 311795-38-7 | |
| Molecular Formula |
C27H27BrN2O |
|
| Molecular Weight (MW) | 475.42 | |
| SMILES | CN(C)C1=C(Br)C=C(C=C1)C2NC3=C(C4=C2C(=O)CC(C)(C)C4)C5=CC=CC=C5C=C3 | |
| InChIKey | NVFRRJQWRZFDLM-UHFFFAOYSA-N |
Glutaminase C-IN-1 is an allosteric inhibitor of mitochondrial Glutaminase C (GAC). By blocking glutaminase activity, the compound suppresses glutamine metabolism and downstream oncogenic signaling pathways driven by Rho GTPases. This targeted inhibition impairs cellular bioenergetics, leading to suppressed cancer cell proliferation, induction of cell cycle arrest, and enhanced apoptosis without impacting normal cellular counterparts. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
48 mg/mL
(100.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.