CAS No. 2403733-82-2
Batch:
Purity:99.57
Chemical Structure
Check the
GLPG3970
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 8-methoxy-6-[7-(2-morpholin-4-ylethoxy)imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1-one | |
|---|---|---|
| CAS Number | 2403733-82-2 | |
| Molecular Formula |
C25H27F3N4O4 |
|
| Molecular Weight (MW) | 504.50 | |
| InChIKey | XASOHFCUIQARJT-UHFFFAOYSA-N |
GLPG3970 is a dual salt-inducible kinase inhibitor targeting SIK1 (IC50 282.8 nM), SIK2 (IC50 7.8 nM), and SIK3 (IC50 3.8 nM). By blocking SIK2 and SIK3 activity, it modulates pro-inflammatory TNF-alpha and immunoregulatory IL-10 cytokine pathways in myeloid cells. This targeted pathway inhibition suppresses inflammatory signaling and reprograms immune cells toward an immunoregulatory phenotype, demonstrating potential application in autoimmune and inflammatory diseases. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(198.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.