CAS No. 1391076-61-1
Batch:
Purity:99.97
Chemical Structure
Check the
GLPG0974
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1391076-61-1 | |
|---|---|---|
| Molecular Formula |
C25H25ClN2O4S |
|
| Molecular Weight (MW) | 485.00 | |
| SMILES | O=C(O)CCCN(C([C@]1(C)N(C(C2=CSC3=CC=CC=C32)=O)CC1)=O)CC4=CC=CC(Cl)=C4 |
GLPG074 is a potent and selective antagonist of human free fatty acid receptor 2 (FFA2/GPR43) with an ICof. By blocking short-chain fatty acid signaling through FFA2, GLPG0974 suppresses acetate-induced activation and intracellular calcium mobilization in immune cells. Downstream, this inhibition reduces neutrophil-based pharmacodynamic markers, including CD11b activation-specific epitope expression, and blocks short-chain fatty acid-stimulated neutrophil migration. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
97 mg/mL
(200.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 97 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.