CAS No. 1206101-20-3
Batch:
Purity:99.80
Chemical Structure
Check the
GLPG0634 analogue
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | |
|---|---|---|
| CAS Number | 1206101-20-3 | |
| Molecular Formula |
C23H18N6O2 |
|
| Molecular Weight (MW) | 410.43 | |
| SMILES | C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5 | |
| InChIKey | RIJLVEAXPNLDTC-UHFFFAOYSA-N |
Biological Activity
GLPG0634 analogue is a selective Janus kinase inhibitor that targets JAK1 (IC50 = 10 nM), JAK2 (IC50 = 28 nM), TYK2 (IC50 = 116 nM), and JAK3 (IC50 = 810 nM). By inhibiting JAK kinase activity, it blocks downstream STAT protein phosphorylation within the JAK/STAT signaling pathway. This disruption reduces cytokine-driven inflammatory responses and suppresses disease progression in preclinical models of autoimmune inflammation.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
0.1 mg/mL
(0.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
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Note: Technical data last updated: Sep 1, 2026.