CAS No. 1320346-97-1
Batch:
Purity:98.52
Chemical Structure
Check the
GLPG0187
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-3-[[2,5-dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl]pyrimidin-4-yl]amino]-2-[(4-methoxyphenyl)sulfonylamino]propanoic acid | |
|---|---|---|
| CAS Number | 1320346-97-1 | |
| Molecular Formula |
C29H37N7O5S |
|
| Molecular Weight (MW) | 595.72 | |
| InChIKey | CXHCNOMGODVIKB-VWLOTQADSA-N |
GLPG0187 is a broad-spectrum integrin receptor antagonist that inhibits αvβ1-integrin with an IC50 value of. By disrupting integrin-dependent cell adhesion and signaling pathways, GLPG0187 inhibits migrasome biogenesis without cytotoxicity. Consequently, blockade of these cell surface receptors impairs cancer cell motility and invasion, leading to potent antitumor activity in preclinical models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
500 mg/mL
(839.32 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | 2 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.