CAS No. 1025015-40-0

Batch: Purity:99.92
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GK921 Chemical Structure
Chemical Structure
Check the GK921 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(2-phenylethynyl)-2-(2-pyrrolidin-1-ylethoxy)pyrido[2,3-b]pyrazine
CAS Number 1025015-40-0
Molecular Formula

C21H20N4O
Molecular Weight (MW) 344.41
SMILES C1CCN(C1)CCOC2=NC3=C(N=CC=C3)N=C2C#CC4=CC=CC=C4
InChIKey MNYJJHBAEYKXEG-UHFFFAOYSA-N

Biological Activity

GK921 is a small-molecule inhibitor targeting transglutaminase 2 (TGase 2). Inhibition of TGase 2 disrupts downstream cellular signaling networks, including NF-kB and AKT/mTOR pathways, leading to altered cellular adhesion, suppressed cell proliferation, and induction of apoptosis. Through TGase 2 inhibition, it attenuates survival signaling and modulates key cellular processes involved in cell migration and tissue remodeling. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 33 mg/mL (95.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Eckert RL, et al. Physiol Rev. 2014;94(2):383-417.

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Note: Technical data last updated: Sep 1, 2026.