CAS No. 1459687-96-7

Batch: Purity:99.86
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GJ103 sodium salt  Chemical Structure
Chemical Structure
Check the GJ103 sodium salt  product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1459687-96-7
Molecular Formula

C16H14N4O3S.Na
Molecular Weight (MW) 366.37
SMILES COC1=CC=CC(=C1)N2C(=NN=C2SCC(=O)[O-])C3=CC=CC=N3.[Na+]

Biological Activity

GJ103 sodium salt is a small-molecule premature termination codon (PTC) read-through agent and an active analog of the read-through compound GJ072. It functions by promoting translational read-through across premature stop codons during mRNA translation, overriding nonsense mutation-mediated translation termination. This mechanism suppresses premature termination signals, enabling the synthesis of full-length, functional proteins and restoring cellular protein expression in models harboring nonsense mutations. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 18 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Du L, et al. J Exp Med. 2009;206(10):2285-97.

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Note: Technical data last updated: Sep 1, 2026.